Ehlers—Danlos syndrome — defect in the synthesis of collagen Type I or III causes progressive deterioration of collagens, with different EDS types affecting different sites in the body, such as joints, heart valves, organ walls, arterial walls.
Connective tissue consists mainly of long fibers embedded in noncellular matter, the ground substance. My boy is playing with this kid several hour a week. Compared with most other kinds of tissue, connective tissue has few cells.
The organisation of the tropocollagen within the microfibrils is highly regular. Note the very fine appearance of the collagen fibres and the lack of apparent specialisations in this type of connective tissue.
Click on a thumbnail image for an annotated enlargement. Mast cells Mast cells are - like macrophages, lymphocytes and eosinophils - in demand when something goes wrong in the connective tissue. The most abundant cell type present in loose connective tissue is the fibroblast.
With a length of about 2. Symptoms can range from mild to disabling. At least the internal elastic lamina should be visible in the smaller arteries which course through the dermis.
The restricted motility of larger molecules in the extracellular space inhibits the spread of microorganisms through the extracellular space. The mast cells' nuclei are centrally located. A typical bacterium 0. The collagen fibre on the right has been cut nearly parallel to its long axis and shows extensive segments of the cross-striated fibrils.
Osteogenesis imperfecta brittle bone disease — caused by poor quality collagen, or insufficient amounts of normal collagen primarily type Inecessary for healthy, strong bones and certain other connective tissues.
Loose Connective Tissue Loose Connective Tissue Loose connective tissue is primarily located beneath epithelial membranes and glandular epithelium, binding these epithelia to other tissues, contributing to the formation of organs. Adipocytes of brown, multilocular adipose tissue contain many lipid droplets.
Regular dense fibrous tissue is the term used to describe tendonsligaments, and aponeuroses fibrous sheets that form attachments for muscleswhere the collagen fibres are precisely oriented in parallel bundles.
Other good candidates are bone sections which contain yellow bone marrow or sections of lymph nodes which are often embedded in adipose tissue. As described on the previous page, the ground substance of connective tissue proper is a porous, well-hydrated, amorphous, compressible gel.
The varieties of connective tissue are: Many support cells and immune cells are typically unpolarized and quiescent, with little cytoplasm and with nuclei containing condensed chromatin. Their number is determined by the number of preadipocytes or lipoblast generated during foetal and early postnatal development.
Macrophages Macrophages arise from precursor cells called monocytes. It also can affect the heart, lungs, and eyes.
A very rich capillary supply and the cytochromes found in the mitochondria give the tissue its characteristic colour. By facilitating access to the area, mast cells facilitate an immune response to the antigen which triggered the release histamine and heparin. They enter connective tissues early in inflammatory reactions, where they phagocytose antigen-antibody complexes.
A curved spine Bleeding gums Problems with the lungs, heart valves, or digestion Epidermolysis bullosa EB. Most connective tissues contain reticular fibres, but only in reticular connective tissue are they the dominant fibre type.
Epithelium covers nearly all external and internal body surfaces. In sections the particles will be visible as dark, black-brown accumulations in the cytoplasm of the macrophages. Ground substance slows the spread of pathogens.a tissue of mesodermal origin that consists of various cells (such as fibroblasts and macrophages) and interlacing protein fibers (as of collagen) embedded in a chiefly carbohydrate ground substance, that supports, ensheathes, and binds together other tissues, and that includes loose and dense.
Connective tissue disease refers to a group of disorders involving the protein-rich tissue that supports organs and other parts of the body. Examples of connective tissue are fat, bone, and cartilage.
Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. Autoimmune disorders involving the connective tissue have complex pathogenetic origins and diverse clinical manifestations.
Systemic sclerosis (or scleroderma) has the highest cause specific mortality of all of the connective tissue diseases, and the majority of patients with systemic sclerosis suffer from serious gastrointestinal tract symptoms.
Connective tissue connects, supports, binds, and separates organs and tissues, forming a framework to support body tissues and organs, for structural and metabolic purposes. In connective tissue, cells are few and dispersed -- they are not in.
Mixed connective tissue disease can lead to serious complications, including: High blood pressure in the lungs (pulmonary hypertension). This condition is the main cause of death in people with mixed connective tissue disease.Download